PI & CMI Trade Names and Active Ingredients containing insulin glulisine. 1 Documents available. Need more information on a Apidra, CMIPI, Insulin glulisine. PI & CMI Trade Names and Active Ingredients containing insulin. 42 Documents Actrapid, PI, Insulin – human (human insulin) Apidra, CMIPI, Insulin glulisine. Apidra PI MKT. #v Page 1. PRODUCT INFORMATION. APIDRA APIDRA [insulin glulisine injection {rDNA origin}] is a recombinant human insulin .

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Pre-filled disposable pens Apidra SoloStar disposable pens are pre-filled and ready for use. If you are apidga sure whether you should start using this medicine, talk to your doctor. The efficacy trials will focus on comparison of glulisine with insulin apidrz.

This is because you could choke. Please check with your doctor or pharmacist before starting any new medicines or over the counter products. Some of the symptoms of an allergic reaction may include:. Level 8, 56 Cawley Street.

Macquarie Park, NSW There are no trials of glulisine use apivra CSII in a purely pediatric population, but in a study in 59 adults with type 1 diabetes comparing glulisine with aspart a apidda frequency of hypoglycemia was found between the two groups.

This difference was particularly pronounced in adolescents 13 to 17 years Storage All medicines should be kept where children cannot reach them. Symptoms of mild to moderate hyperglycaemia include:.

A randomized, crossover, open study in order to compare treatment satisfaction with glargine plus glulisine vs NPH insulin plus glulisine in newly diagnosed children and adolescents with type 1 diabetes.

Push the needle through the rubber top of the vial and inject the air into the vial. Once all the insulin is used, you cannot replace the cartridge. Other adverse effects When glulisine was compared with RHI in a small crossover trial in 10 adolescents and 10 children with type 1 diabetes, no safety concerns arose. Apidra is supplied in New Zealand by:. Several large trials have studied glulisine in adult patients with type 1 and type 2 diabetes, but data in the pediatric population are limited.


Accessed September 6, Ask your doctor if you have any questions about why Apidra has been prescribed for you.

Your doctor, pharmacist or diabetes educator can provide you with some helpful information. Ask your doctor, pharmacist or diabetes educator to answer any questions you may have. Carefully follow the instructions provided with the pen, for loading a cartridge, attaching a needle, performing a safety test and administering the insulin injection. One study, utilizing aapidra high performance liquid chromatography apidraa assess resistance to isoelectric precipitation of various types of insulin, 16 found that the resistance was highest for aspart and lowest for glulisine, but the clinical significance of this is unclear.

Do not shake the vial.

Discard the pre-filled pen within 28 days of first use. Withdraw the needle without drawing up any insulin. Apidra SoloStar is a pre-filled disposable pen containing a 3mL cartridge of Apidra. Quality of life No specific studies have addressed quality of life QoL in patients on glulisine. Cold insulin is more painful to inject. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

Tolerability Flexibility of administration In general, use of rapid-acting insulin analogs gives greater flexibility for the timing of injections, especially important for children and teenagers. Published online Nov Discard the cartridge within 28 days of first use.

Make sure you are using the correct injection pen, cartridge or vial. Efficacy and safety of insulin glulisne in japanese patients with type 1 diabetes mellitus; using glargine as basal insulin [Abstract Number PO] Diabetes.

Open in a separate window. Taking other medicines Tell your doctor if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

TGA eBS – Product and Consumer Medicine Information

If severe hypoglycaemia is not treated, it can cause brain damage and death. Rates of hypoglyemia are similar to rates with other rapid-acting analogs. Despite a significantly higher percentage of patients on glulisine achieving ADA age-specific HbA 1c targets at endpoint Insulin lispro in treatment of children and adolescents with type 1 diabetes and its effect li quality of life.


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In solution, insulin molecules exist in equilibrium between monomers, dimers, tetramers, hexamers, and higher-order aggregates. Consider dosage reduction or discontinuation of TZD if heart failure occurs. There were no trials comparing the efficacy of glulisine with aspart in pediatric patients.

Your doctor and pharmacist have a full list of medicines with which you must be careful or avoid while using Apidra. It is important to keep using Apidra even if you feel well. Human insulin is best absorbed in its monomeric form but, at physiologic pH, normal insulin molecules tend to associate into dimers and subsequently hexamers in the presence of zinc. Glulisine has not been approved by the Food Drug Administration for use in children or adults via CSII, but two clinical aapidra27 and two in vitro studies have investigated its use.

All medicines have risks and benefits. When glulisine was compared with aspart in CSII in 59 adult patients with type 1 diabetes the frequency of infusion-site reactions was similar between oi two groups. Tell your doctor if you are pregnant or plan to become pregnant.

The role of insulin glulisine to improve glycemic control in children with diabetes mellitus

Upon registration, patient receives all program details. However, it has been shown to be noninferior to lispro in terms of efficacy and safety as part of a basal-bolus regimen in pediatric patients with type 1 diabetes. A small crossover trial of 10 children and 10 adolescent patients with type 1 diabetes comparing RHI and glulisine found no severe hypoglycemic events.

Make sure the tip of the needle is in the insulin and withdraw the correct dose into the syringe.